Zika virus (ZKV) is a single-stranded RNA (ssRNA(+)) virus of the Flaviviridae genus. Other members of the Flavivirus genus, such as West Nile virus and dengue virus, are increasingly gaining attention due to their re-emergence and incidence in different areas of the world. Further environmental as well as demographic considerations propose that novel or known flaviviruses will likely re-emerge in the future. Nonetheless, it was not until recently that flaviviruses have been considered interesting candidates for drug design. The flaviviral replication complex presents as a very promising target for development of antiviral compounds. Read more about Zika.
| To study the function of Zika virus (ZKV), Vigene offers: |
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● 14 ZKV open reading frames (ORFs) as plasmid DNA, AAV, adenovirus ● Non-infectious ● Used individually or as a group ● Works with cells or for in vivo research purposes |
The genome of the ZKV encodes 14 open reading frames (ORFs). The research of ZKV function and the development of ZKV vaccine requires in-depth understanding of the function of each ORF on ZKV. The virion is enveloped, spherical, and about 50 nm in diameter. The surface proteins are arranged in an icosahedral-like symmetry. ZKV encodes a large polyprotein precursor. This precursor is co- and post-translationally processed by viral and cellular proteases into three structural proteins; building the capsid, and seven non-structural proteins involved in virus replication.
| Zika Key facts |
● Zika virus disease is caused by a virus transmitted primarily by the Aedes mosquitoes. ● Persons with Zika virus disease may have symptoms which include mild fever, skin rash, conjunctivitis, muscle and joint pain, malaise or headache. Such symptoms normally last for 2-7 days. ● Scientific consensus states that Zika virus is the cause of microcephaly and Guillain-Barré syndrome. Links to other neurological complications have also been investigated. |
| Protein Name | Viral Protein Locus ID | ORF-ID | Price |
|---|---|---|---|
| Complete ORF Set | ZV-1 | ZV-Set | From $1,999.00 |
| anchored capsid protein C | ancC | ZV-AC | From $249.00 |
| capsid protein C | C | ZV-CC | From $249.00 |
| membrane glycoprotein precursor M | preM | ZV-PreM | From $249.00 |
| protein pr | pr | ZV-Pr | From $249.00 |
| membrane glycoprotein M | M | ZV-M | From $249.00 |
| envelope protein E | E | ZV-E | From $249.00 |
| nonstructural protein NS1 | NS1 | ZV-NS1 | From $249.00 |
| nonstructural protein NS2A | NS2A | ZV-NS2A | From $249.00 |
| nonstructural protein NS2B | NS2B | ZV-NS2B | From $249.00 |
| nonstructural protein NS3 | NS3 | ZV-NS3 | From $249.00 |
| nonstructural protein NS4A | NS4A | ZV-NS4A | From $249.00 |
| protein 2K | 2K | ZV-2K | From $249.00 |
| nonstructural protein NS4B | NS4B | ZV-NS4B | From $249.00 |
| RNA-dependent RNA polymerase NS5 | NS5 | ZV-NS5 | From $249.00 |
Zika virion RNA is infectious and serves as the genome and viral messenger RNA. The entire genome is translated into a 3,419 aa long polyprotein, which is processed co- and post-translationally by both host and viral proteases.
ZKV replication occurs in the cytoplasm in mammals, and nuclear in insects.
The following is ZKV replication:
It is pertinent to know that although precise details of flavivirus replication have seen significant advances in the past years, numerous aspects remain that are not fully understood.
