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Zika virus (ZKV) is a single-stranded RNA (ssRNA(+)) virus of the Flaviviridae genus. Other members of the Flavivirus genus, such as West Nile virus and dengue virus, are increasingly gaining attention due to their re-emergence and incidence in different areas of the world. Further environmental as well as demographic considerations propose that novel or known flaviviruses will likely re-emerge in the future. Nonetheless, it was not until recently that flaviviruses have been considered interesting candidates for drug design. The flaviviral replication complex presents as a very promising target for development of antiviral compounds. Read more about Zika.
|To study the function of Zika virus (ZKV), Vigene offers:|
● 14 ZKV open reading frames (ORFs) as plasmid DNA, AAV, adenovirus
● Used individually or as a group
● Works with cells or for in vivo research purposes
The genome of the ZKV encodes 14 open reading frames (ORFs). The research of ZKV function and the development of ZKV vaccine requires in-depth understanding of the function of each ORF on ZKV. The virion is enveloped, spherical, and about 50 nm in diameter. The surface proteins are arranged in an icosahedral-like symmetry. ZKV encodes a large polyprotein precursor. This precursor is co- and post-translationally processed by viral and cellular proteases into three structural proteins; building the capsid, and seven non-structural proteins involved in virus replication.
|Zika Key facts|
● Zika virus disease is caused by a virus transmitted primarily by the Aedes mosquitoes.
● Persons with Zika virus disease may have symptoms which include mild fever, skin rash, conjunctivitis, muscle and joint pain, malaise or headache. Such symptoms normally last for 2-7 days.
● Scientific consensus states that Zika virus is the cause of microcephaly and Guillain-Barré syndrome. Links to other neurological complications have also been investigated.
|Protein Name||Viral Protein Locus ID||ORF-ID||Price|
|Complete ORF Set||ZV-1||ZV-Set||From $1,999.00|
|anchored capsid protein C||ancC||ZV-AC||From $249.00|
|capsid protein C||C||ZV-CC||From $249.00|
|membrane glycoprotein precursor M||preM||ZV-PreM||From $249.00|
|protein pr||pr||ZV-Pr||From $249.00|
|membrane glycoprotein M||M||ZV-M||From $249.00|
|envelope protein E||E||ZV-E||From $249.00|
|nonstructural protein NS1||NS1||ZV-NS1||From $249.00|
|nonstructural protein NS2A||NS2A||ZV-NS2A||From $249.00|
|nonstructural protein NS2B||NS2B||ZV-NS2B||From $249.00|
|nonstructural protein NS3||NS3||ZV-NS3||From $249.00|
|nonstructural protein NS4A||NS4A||ZV-NS4A||From $249.00|
|protein 2K||2K||ZV-2K||From $249.00|
|nonstructural protein NS4B||NS4B||ZV-NS4B||From $249.00|
|RNA-dependent RNA polymerase NS5||NS5||ZV-NS5||From $249.00|
Zika virion RNA is infectious and serves as the genome and viral messenger RNA. The entire genome is translated into a 3,419 aa long polyprotein, which is processed co- and post-translationally by both host and viral proteases.
ZKV replication occurs in the cytoplasm in mammals, and nuclear in insects.
The following is ZKV replication:
It is pertinent to know that although precise details of flavivirus replication have seen significant advances in the past years, numerous aspects remain that are not fully understood.